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排序方式: 共有4368条查询结果,搜索用时 62 毫秒
31.
Nazl Turan Yücel Ümmühan Kandemir Ümide Demir
zkay
zgür Devrim Can 《Molecules (Basel, Switzerland)》2021,26(11)
Vortioxetine is a multimodal antidepressant drug that affects several brain neurochemicals and has the potential to induce various pharmacological effects on the central nervous system. Therefore, we investigated the centrally mediated analgesic efficacy of this drug and the mechanisms underlying this effect. Analgesic activity of vortioxetine (5, 10 and 20 mg/kg, p.o.) was examined by tail-clip, tail-immersion and hot-plate tests. Motor performance of animals was evaluated using Rota-rod device. Time course measurements (30–180 min) showed that vortioxetine (10 and 20 mg/kg) administrations significantly increased the response latency, percent maximum possible effect and area under the curve values in all of the nociceptive tests. These data pointed out the analgesic effect of vortioxetine on central pathways carrying acute thermal and mechanical nociceptive stimuli. Vortioxetine did not alter the motor coordination of mice indicating that the analgesic activity of this drug was specific. In mechanistic studies, pre-treatments with p-chlorophenylalanine (serotonin-synthesis inhibitor), NAN-190 (serotonin 5-HT1A receptor antagonist), α-methyl-para-tyrosine (catecholamine-synthesis inhibitor), phentolamine (non-selective α-adrenoceptor blocker), and naloxone (non-selective opioid receptor blocker) antagonised the vortioxetine-induced analgesia. Obtained findings indicated that vortioxetine-induced analgesia is mediated by 5-HT1A serotonergic, α-adrenergic and opioidergic receptors, and contributions of central serotonergic and catecholaminergic neurotransmissions are critical for this effect. 相似文献
32.
The benefits of natural honeybee products (e.g., honey, royal jelly, beeswax, propolis, beevenom and pollen) to the immune system are remarkable, and many of them are involved in the induction of antibody production, maturation of immune cells and stimulation of the immune system. The type of plants in the geographical area, climatic conditions and production method have a significantly influence on the nutritional quality of honey. However, this variability can influence consumer liking by the sensory attributes of the product. The aim of this work was to compare the most popular honeys from Poland in terms of nutritional value, organoleptic properties and antioxidant activity. In the study, five varieties of honey (honeydew, forest, buckwheat, linden and dandelion) from conventional and organic production methods were tested. The nutritional characteristics of honey samples included acidity, content of water, sugars, vitamin C, HMF and phenolics (total and flavonoids), while honey color, taste, aroma and consistency were investigated in the organoleptic characteristics. The antioxidant activity was determined in water- and ethanol-soluble honey extracts using DPPH and ORAC tests. The results showed that organoleptic and nutritional characteristics of popular Polish honeys differ significantly in relation to plant source and production method. The significant effect of honey variety on the content of HMF, saccharose and phenolics, as well as acidity and antioxidant capacity were noted. The impact of variety and variety × production method interaction was significant in the case of the content of vitamin C, glucose and fructose. A visible difference of buckwheat and forest honeys from other samples was observed. The highest content of total phenolics with antioxidant activity based on the SET mechanism was found in buckwheat honeys, while forest honeys were richer in flavonoids. 相似文献
33.
Dr. Atena B. Solea Dr. Christophe Curty Prof. Dr. Katharina M. Fromm Prof. Dr. Christophe Allemann Prof. Dr. Olimpia Mamula Steiner 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(55):e202201772
The toxicity of phosgene (COCl2) combined with its extensive use as a reactant and building block in the chemical industry make its fast and accurate detection a prerequisite. We have developed a carboxylic derivative of 5,6-pinenepyridine which is able to act as colorimetric and fluorimetric sensor for phosgene in air and solution. For the first time, the formation of a pyrido-[2,1-a]isoindolone was used for this purpose. In solution, the sensing reaction is extremely fast (under 5 s), selective and highly sensitive, with a limit of detection (LOD) of 9.7 nM/0.8 ppb. When fixed on a solid support, the sensor is able to detect the presence of gaseous phosgene down to concentrations of 0.1 ppm, one of the lowest values reported to date. 相似文献
34.
35.
杭州大剧院风压分布的风洞试验研究 总被引:4,自引:0,他引:4
杭州大剧院外观造型新颖独特,由一个近似为椭球的双曲面屋盖和一个倒置的圆锥面玻璃幕墙相交形成大剧院的主体建筑的外轮廓.本文结合该主体结构的抗风设计要求,制作了1:200刚性模型进行结构表面脉动风压平均风压分布的风洞试验研究,详细介绍了风洞试验及数据处理方法,讨论了在不同风向角下椭球面屋盖和圆锥面玻璃幕墙的风压分布.为了便于整体结构设计,本文根据结构的实际情况对椭球面和圆锥面进行分块并给出相应的分块风压数据,最后根据各风向角下的风压分布特征给出了整体结构抗风设计的最不利风向角. 相似文献
36.
惯性系统三轴综合测试转台总体设计若干问题的探讨 总被引:3,自引:0,他引:3
本文从框架形式、总体布局、轴承的种类和布置方式等方面,讨论了惯性系统三轴综合测试转台总体设计中的若干问题,从设计、制造和使用等方面阐述了各种总体布局形式的优缺点,并提出了自己的相应看法,最后讨论了目前惯导测试设备研究领域需要研究的关键技术。 相似文献
37.
C. -H. Chien Y. -C. Chen C. -C. Hsieh Y. -T. Chiou Y. -D. Wu T. -P. Chen 《Experimental Mechanics》2004,44(2):214-220
With the increasing application of flip-chip technology in the microelectronics industry, the adhesion strength of interfaces
in flip-chip microelectronic structures has become an important issue for manufacturing and operation. In this paper we present
an experimental investigation of the adhesive strength of underfill material to solder mask coated FR-4 substrate under thermal
cycling. The effects of the number of thermal cycles on interfacial strength were investigated by using the button shear test.
The relationship between interfacial strength and the thickness of solder mask was also examined. Furthermore, the morphologies
of fracture surfaces of the test specimens were analyzed by scanning electron microscopy. The results of this study show that
the interfacial strength of the underfill/solder mask/substrate joint was significantly reduced by thermal fatigue. Finally,
the degradation behavior and possible mechanisms were then determined on the basis of these observations. 相似文献
38.
39.
鼓膜法测定纳米多孔氧化铝薄膜的弹性模量 总被引:1,自引:4,他引:1
本文的多孔氧化铝薄膜含有直径均一、互相平行且与表面垂直的有序纳米孔阵列。它有广阔的应用前景。多孔氧化铝膜与氧化铝陶瓷材料的宏观力学性能有很大的区别。本文用鼓膜法结合实时电子散斑干涉(ESPI)技术,测量薄膜压力与离面位移的关系,再用周边固支平板小挠度模型计算出多孔氧化铝薄膜的宏观弹性模量。本实验中厚76微米的多孔氧化铝薄膜的宏观弹性模量为32.5GPa,比热压氧化铝陶瓷的弹性模量几乎小一个数量级,主要是由于晶相和细观结构不同造成的。这种方法较适合测量此类结构薄膜的力学性能。 相似文献
40.
讨论了一种适用于双轴测试转台的全数字化控制系统结构。该系统采用了多单片机并行实现的主从分布式控制方法,不仅大大简化了系统硬件设计,提高了可靠性;而且其控制器完全由软件来实现,易于实现模拟电路难以实现的复杂的控制规律;同时也为在不改变硬件的前提下进一步扩展系统功能,改善系统的动、静特性提供了基础。实验表明,文中提出的全数字化控制系统结构完全能满足双轴测试转台的控制需要。 相似文献